Pemphigus is an autoimmune disorder. The immune system produces antibodies against specific proteins in the skin and mucous membranes. These antibodies break the bonds between skin cells. This leads to the formation of a blister. The exact cause is unknown.
About 50% of people with this condition first develop painful blisters and sores in the mouth, followed by skin blisters. Skin lesions may come and go.
The skin sores may be described as:
- Peeling or easily detached
- Treatment for Pemphigus Vulgaris
The treatment is divided into three phases:
- Control: Period of intense therapy given to suppress disease activity until no new lesions appear. The duration of this phase is weeks.
- Consolidation: Drugs and doses are maintained until complete clearance of lesions.
- Maintenance: Medications can be gradually tapered aiming for the lowest dose that prevents new lesions from appearing.
Relapse may occur at any time, resulting in renewed disease control effort.